Does the antagonist oppose the internal need?
Inner Challenge is a better word.
In the following sense, yes. If the antagonism is aware of the hero’s destiny and potential (which is to replace it and return to a State of Perfection), then it will do all it can to keep the hero repressed, immature and impotent.
In Return of the Jedi (1983), the Emperor knows that it is Luke’s destiny to replace him.
In Jason and the Argonauts (1963), King Aeetes is happy to send Jason off on pursuits that he believes will keep him ignorant.
The Inner Challenge is most often opposed by various archetypes who, for good or bad reasons, hold the hero back.
In Star Wars (1977), Uncle Owen wants Luke to stay on the farm.
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